Pigment epithelium-derived factor (PEDF) inhibits advanced glycation end product-induced retinal vascular hyperpermeability by blocking reactive oxygen species-mediated vascular endothelial growth factor (VEGF) expression

Pigment epithelium-derived factor (PEDF) inhibits advanced glycation end product-induced retinal vascular hyperpermeability by blocking reactive oxygen species-mediated vascular endothelial growth factor (VEGF) expression Sho-ichi Yamagishi, Kazuo Nakamura, Takanori Matsui, Yosuke Inagaki, Katsuhiko Takenaka, Yuko Jinnouchi, Yumiko Yoshida, Tetsuro Matsuura, Isao Narama, Yoshihiro Motomiya, Masayoshi Takeuchi, Hiroyoshi Inoue, Akihiko Yoshimura, Richard Bucala, Tsutomu Imaizumi From the Department of Internal Medicine III and Radioisotope Institute for Basic and Clinical Medicine, Kurume University School of Medicine, Kurume, Japan; the Department of Pathology, Faculty of Pharmaceutical Science, Setsunan University, Hirakata, Japan; Suiyukai Clinic, Kashihara, Japan; the Department of Pathophysiological Science, Faculty of Pharmaceutical Science, Hokuriku University, Kanazawa, Japan; the Division of Molecular and Cellular Immunology, Medical Institute of Bioregulation, Kyushu University, Fukuoka, Japan; and the Department of Internal Medicine, Yale University School of Medicine, New Haven, USA. Running Title: PEDF and diabetic retinopathy